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Re: cabel post# 5748

Tuesday, 12/11/2012 6:33:03 AM

Tuesday, December 11, 2012 6:33:03 AM

Post# of 16750
The author of that article has made a very astute observation and it makes sense. We know (& mgmnt has reiterated several times), that they strongly expect PFS for RFA alone to be 12 months based on historical study. The longer it takes to trigger 380 events, it is better for TDOX as the only reason for the delay is TDOX is working well. If you divide evenly the pts who are receiving RFA alone vs RFA+TDOX to 350 each and if the first 350 events are due to RFA pts (< = 12 months), we had to wait for another 30 events before unbinding the trial. This wait has been significant which strongly supports the hypothesis of events triggered for TDOX pts is longer than for RFA pts.