PROLOR Biotech, Inc. (PBTH)

[surf1944]

7:36AM PROLOR Biotech announced that the company will present preclinical data on its long-acting clotting Factor VIIa; demonstrated a markedly enhanced pharmacokinetic profile and increased exposure (PBTH) 4.86 : Top-line results of the Factor Vlla-CTP studies have been previously reported by PROLOR. The results show that when compared to commercially available Factor VIIa, Factor VIIa-CTP in hemophilic mice demonstrated a markedly enhanced pharmacokinetic profile and increased exposure, as evidenced by a prolonged hemostatic effect and improved recovery, which is a measure of clotting activity. Compared to commercially available Factor VIIa, Factor VIIa-CTP in hemophilic mice demonstrated superior thrombin generation parameters, and it resulted in greater survival of the subjects. In these studies, the specific activity of Factor VIIa-CTP was comparable to commercial Factor VIIa. The study data also show that administration of Factor Vlla-CTP by subcutaneous injection resulted in improved bioavailability and prolonged exposure compared to intravenous administration of Factor Vlla-CTP.