Something very special takes place using Tivantinib in NSCLC - HR for PFS was excellent - HR for OS was very poor The same picture was observed in PhII in c-MET low ITT pts population.
These results are very much different from MetMab PhII data in NSCLC - 52% of all pts were C-MET high - HR~1 was in ITT pts for both PFS and OS
The bottom line In c-MET low NSCLC pts population, MetMed results make sense but Tivantinib results do not "make sense".
Appears that these c-MET inhibitor drugs have different mechanisms of action.
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