Saturday, November 24, 2012 9:53:07 AM
there is no way to deliver the MANF protein at the current time:
Advantages and disadvantages. Adenoviral vectors have a high transduction efficiency, are capable of containing DNA inserts up to 8 kilobases, have extremely high viral titers (on the order of 1010-1013), and infect both replicating and differentiated cells. Also, since they lack integration, they can not bring about mutagenic effects caused by random integration into the host genome. Disadvantages of adenoviral vectors include the following: (1) expression is transient since the viral DNA does not integrate into the host, (2) viral proteins are expressed in the adenoviral vector following administration into the host, and (3) adenoviral vectors are an extremely common human pathogen and in vivo delivery may be hampered by prior host immune response to one type virus.
this may change in the future ????
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