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Friday, November 09, 2012 9:55:37 PM
written by the senior authors, of the research published in the Ramesh et al paper.
This is freely available and has the picture I posted.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389810/
Here is the last paragraph of the Conclusions section.
Currently patients with APS are treated chronically with anticoagulation medications such as
heparin or warfarin. Despite long-term use of the anticoagulants, recurrent thrombosis can
occur in APS patients. Furthermore, use of anticoagulants is fraught with complications
including bleeding episodes and osteopenia. With the recent new knowledge that has
been gained regarding the processes that underlie aPL actions on endothelium, we anticipate
that novel interventions can be developed that directly target the pathogenetic mechanisms,
thereby affording greater efficacy and fewer complications in the management of this
potentially life-threatening disorder
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