Avid Bioservices Inc (CDMO)

[freethemice]

I think the arguments about bavi working inside, or outside, or whatever, is a matter of semantics.
I would define the tumor microenvironment as the tumor mass itself, and the space inside of it, and the
surrounding tissue which is under the influence of the chemokines and cytokines released by the tumor
cells and the leukocytes which have infiltrated the tumor and the surrounding tissue in response to the
tumor. Bavi will bind to PS expressed on the endothelial cells of the tumor vasculature, which are inside the
tumor, and to any PS expressed on the tumor cells themselves, or to PS on exosomes and ectosomes
which can be both inside and outside of the tumor. I think of the tumor microenvironment as the tumor
and its "sphere of influence" surrounding the tumor. Bavi can modify the characteristics of that environment
from one which is immunosuppressive and tumorigenic, to one which is immunostimulatory and tumoricidal.