For CP patients, 18% (14/76) achieved a major cytogenetic response (MCyR) with a mean time to MCyR onset of 3.5 months. The median duration of MCyR for these patients was 12.5 months
For reference, Ponatinib achieved a 60.7% (65/107) MCyR in a similar setting (CP failed 2 tki's) in less time (10.5 months). In AP, the ponatinib benefit was 39.4% (13/33)versus 14% 5/35) for SYNRIBO
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