Avid Bioservices Inc (CDMO)

[freethemice]

The whole idea as talked about by Thorpe is to switch the microenvironment so that the dendritic cells are
then allowed to mature and present antigen to T cells and start the whole adaptive immune response.
That is why he refers to "awaking the adaptive immune response", because it is blocked and then
becomes unblocked. Yes, bavi does work through the innate immune response, but it also has the ability
to utilize the adaptive immune response. You might want to reread that paper. The F98 tumor is poorly
immunogenic in the rat model. Thorpe also talks about this in his NYAS webcast. Here is the survival data.
You can see that it is only the rats that received the combination treatment of radiation and antibody that developed immunity.


The point with the serum therapy is that antibodies were being injected and they neutralized the diptheria toxin
and saved the lives of the patients. It is an old example of an immunotherapy.