Prana Biotechnology (PRAN)

[frobinso]

Here are some things stated about PBT2 from Prana's website, and notice the comments about oligomers in the first three bullets:

Clinical Program

PBT2


PBT2 has exhibited superior performance in a variety of laboratory and animal screening tests designed to assess the ability of the compound to interfere with the toxic mechanisms of AD & HD. The positive effects on basic function delivered by the actions of PBT2 include:

(i) Anti Abeta and mutant huntingtin (mHtt) effects:
• Reduces Abeta Aggregation
• Promotes Dissolution of Abeta oligomers
• Prevents toxicity of Abeta oligomers (preventing binding to NMDA receptors)
• Promotes Abeta Degradation and Clearance
• Redistributes Abeta-Sequestered Metals back into neurons and other cells
• Reduces mHtt Aggregation

(ii) Neuroprotective and neurotrophic effects
• Redistributes metals into neurons and modulates intracellular signalling
pathways
• Reduces potential for glutamate excitotoxicity
• Restores Synaptic Plasticity (LTP and Spine Density) ie promotes neuronal
regrowth
• Prevents free radical production (silences redox activity or redox active
metals)
• Reduces tau hyperphosphorylation
• Reduces brain striatal tissue degeneration