AI
Saturday, October 20, 2012 7:26:12 PM
probe IRDye800CW to make 800CW-PGN635.
The top part of the antibody, F(ab')2, is the part of PGN635 that is called PGN650. It is then linked to
the radioisotope iodine-124 to make I124-PGN650.
The Fab end, or variable region, of the antibody is what binds to beta2-GP1, which binds to PS.
A macrophage would bind to PGN635 via the constant region, or Fc end, of the antibody using the Fc-gamma
receptors on the macrophage. Note that this cannot happen with PGN650 since the Fc end has been cut off by using
the enzyme pepsin. So I124-PGN650 won't interact with macrophages and DCs, but will block the exposed PS.
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