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Re: skiguy28 post# 6348

Wednesday, 10/17/2012 12:00:23 PM

Wednesday, October 17, 2012 12:00:23 PM

Post# of 30990
Bexarotene/Anatabloc partnership?

Both of the articles linked by skiguy/alias-sliencetwain/alias-feurstein/alias-??? are talking about a cancer drug, Bexarotene. First take a look at that list of side effects for Bexarotene that I reprinted for your convenience below. And even though Bexarotene is already on the market, they are saying that it will be 5 to 7 years before it can approved for use on alzheimers patients. The funny thing is that it has been on the market for a while now and in fact, the patent expires next year.

Besides the side effects, there's this from one of the articles; "If a phase I clinical trial was to start today, it still would take five to seven years before ReXceptor could finish testing the drug in Alzheimer's patients and win FDA approval to start selling bexarotene for use in treating Alzheimer's, said Michael Haag, a technology transfer official at CWRU who is serving as ReXceptor's CEO. And there's no telling whether the drug will make it through clinical trials or whether the company will attract the “hundreds of millions of dollars” that will be needed to complete all of them, Mr. Haag said."

Given these facts, this is actually even more of an opportunity for Star than it might appear at first blush. 1) Anatabloc is extremely safe with no negative side effects. 2) Anatabloc is available now and human trials are already underway, and 3) This is a perfect opportunity for this drug company to partner with Star.

I believe that Anatabloc would, at a minimum, reduce many of Bexarotene's negative side effects. The half life of Bexarotene in the human body is 7 hours, very similiar to anatabine. And by combining Bexarotene with a anatabine, they are creating another patentable substance. Both companies would benefit. This is a perfect example of the kind of "improved and re-patentable" drug that Nuke John has spoken of before.

From skiguy/alias-sliencetwain/alias-feurstein/alias-???


Bexarotene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache, weakness, tiredness, increased sensitivity to cold, increase in weight, depression, joint or muscle pain, thin-brittle hair or fingernails, constipation, rash, dry skin, redness, scaling, or itching of the skin, hair loss, swelling of ankles-feet & legs, difficulty falling asleep or staying asleep, nausea, vomiting, diarrhea. Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: sudden or ongoing back or stomach pain, severe and ongoing nausea and vomiting, fever or sore throat or chills or other signs of infection, or changes in vision. Additionally Bexarotene may increase the levels of cholesterol and other fats in your blood and may stop your thyroid gland from working normally.

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