Dynavax Technologies Corporation discovers, develops, and intends to commercialize innovative therapeutic products to treat and prevent infectious diseases, allergies, and cancer. Our versatile, proprietary approaches alter specific immune responses by activating a unique receptor called Toll-Like Receptor 9 (TLR9) found on certain immune system cells. To target TLR9, we are using immunostimulatory sequences, or ISS, which are short DNA sequences that enhance the ability of the immune system to fight disease and control chronic inflammation.
Our clinical development pipeline includes: HEPLISAV™, a hepatitis B vaccine in Phase 3 clinical trials; a hepatitis B therapy in a Phase 1 trial; and a cancer therapy for non-Hodgkin's lymphoma (NHL) in a Phase 2 trial and for metastatic colorectal cancer in a Phase 1 trial. Our preclinical program in asthma and chronic obstructive pulmonary disease (COPD) is partnered with AstraZeneca. Our preclinical work on an influenza vaccine is funded in part by the National Institutes of Health (NIH), while our colorectal cancer clinical trial and preclinical hepatitis C therapeutic program are funded by Symphony Dynamo, Inc. While the NIH and Symphony provide program support, Dynavax has retained rights to seek strategic partners for future development and commercialization
