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Re: jakedogman1 post# 97272

Tuesday, 10/02/2012 3:30:57 PM

Tuesday, October 02, 2012 3:30:57 PM

Post# of 346543
Well if you want to entertain paranoia regarding test evaluations. I recall (possibly fallaciously) that the PFS of the first line study was apparently anomalous. The blinded independent evaluation found that the placebo arm PFS was more than one sigma longer than the historically expected value for first line lung cancer. Possibly two standard deviations and clearly an outlier. While the Bavi PFS was only slightly longer than the placebo. The individual investigator numbers were in line with expectations for the placebo arm. It appeared to me at the time that possibly the scans submitted to the independent review had been randomized, blending the placebo and Bavi arm data. Could the encoding have been tampered with or a gross oversight have occurred ?

If this is so this should not effect MOS. So I am still hopeful.
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