Avid Bioservices Inc (CDMO)

[entdoc]

Bungler,the most interesting thing about PPHM pipeline is how their treatments are complementary, if its to large for Bavi, hitit with cotara,2C3, or small-molecule cytotoxin tTF which can be carried on Cotara- or Bavi-like MAB missile constructs. Cotara has been around long enough to have a very defined action and side-effect profile, and technology can deal with those. The advantage of delivering cytotoxins SPECIFICALLY to large cancer cores, the center of tumor, is obvious, and can be done. In the meanwhile, if CotaraMAB is too large to pass through the blood brain barrier, it probably won't back-diffuse through it either, so PPHM has completed PII Cotara trials for brain Cancer, and awaits funding of this near-lock PIII MAB, delivered into the spinal fluid and directly into GBM tumor. In this case the delivery system (intrathecal catheter) is probably as important as the cytotoxin. The one stumbling block with Cotara GBM trials is that double-blinded studies have not been done, and perhaps cannot be done via catheter into bulk of brain tumor mass. PPHM has a near-embarrassment of riches. Stockholders need to know just how much value is there...and not let new money steal the technology. Gawd! Then there is Avid, PPHM's own FDA-approved MAB production facility capapble of boutique orders from other biotech and large scale production of.... Looks like it is Bavi first.