Avid Bioservices Inc (CDMO)

[freethemice]

The doubters all seem to be basing their red flags on the old paradigm. They think
of bavituximab as if it were a small molecule drug. So when the MOS is much better than
the old rule MOS = 2 X PFS they don't understand how it could be true, so there must
be something wrong, or worse. They fail to take the time to learn anything about the
unique MOA that bavi has. They understand that it is an antibody and the target is PS, but
fail to understand anything else about it. For example, that by targeting the tumor
vasculature the effects of the antibody are greatly magnified when each blood vessel
feeds hundreds, or thousands, of tumor cells downstream. The fact that bavi can
both block the immunosuppressive effects of PS, and at the same time switch the tumor
associated macrophages (TAMs) from type M2 to M1, and cause dendritic cells
to mature, and reduce the numbers of myeloid-derived suppressor cells (MDSCs), and
allow adaptive immunity to work again, is totally lost on them. There is plenty of info out
there if they would care to make the effort to learn something new. For example:
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=78445110