BOSTON (MarketWatch) -- Shares of ArQule Inc. ARQL -25.69% plunged 23% to $5.15 on Wednesday on safety concerns about its drug candidate tivantinib for the treatment of lung cancer. In a federal filing made Tuesday, ArQule said that its Japanese development partner, Kyowa Hakko Kirin Co., has temporarily suspended a Phase III clinical trial testing tivantinib in combination with the lung-cancer therapy Tarceva over concerns that some of the patients had developed interstitial lung disease. As of Wednesday, shares of ArQule are down 9% from the start of the year.
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