Helicos Biosciences Corporation (fka HLCSQ)

[highfive]

http://sfgf.stanford.edu/documents/solexa_docs/Technology_Overview/general_technology.pdf


read helicos patent then look at slide or page 28 and 29

from helicos patent....

The present invention involves using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Generally, the invention includes a passive vacuum source and one or more valves and sensors for operating and monitoring the apparatus and methods. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.

In one aspect, the invention relates to a lighting system including a first light source for analyzing a sample of interest and a second light source. The first light source defines a first optical path that intersects a sample of interest and the second light source operates with the first light source for determining a position of the first optical path


HELICOS PATENT 109 IN a nutshell

1. A system for analyzing a sample, comprising:a flow cell;a lighting system for illuminating the sample in the flow cell; andan optical instrument for viewing the sample in the flow cell,wherein the lighting system comprises:one or more analytical light sources, each light source defining an optical path that intersects the sample; anda focusing light source operating with any one of the analytical light sources to focus said optical instrument on the sample.


read the above Helicos patent then click on the Illumina slide number 29 read the Helicos patent and view slide 29



All Illumina did with the TIRF was made it "Internal" so they basically just hid it in one of their machines lol




you see, they have the Big mac, I have the Big Mic....we both use two all beef patties special sauce lettuce cheese...EXCEPT my burgers dont use a sesame seed bun

Mr Mcdowell in "Coming to America"