I believe
that what is happening is that bavi is altering the tumor microenvironment by masking PS and by
directly switching macrophages from M2 to M1. When neutrophils are recruited to the tumor they then
remain in the N1 state instead of being switched to the tumorgenic N2 state, as they would be if bavi wasn't used.
It would seem to me, (speaking logically, not scientifically), if the immune response remains after bavi has cleared the system (as it did in the castration resistant rats), that it's somehow the unmasking of the tumor to the immune system that precipitates the natural immune response to the tumor and the changes to the macrophages and neutrophils. The unmasking seems to be instructive to the body, allowing it to recognize other, later tumor developments. Else, how do the switches continue after bavi has cleared the system?
I would wonder if, since the mechanism of solid tumor cancer action centers around switching off the immunesuppressive signals of PS ... if once a person is treated successfully with bavi, wouldn't they have similar immune response against ANY tumor that began to grow that flipped PS. Speaking logically, once the body has been taught to recognize disease that uses PS to mask itself, might not a successful treatment provide immunity to all forms of PS modulated disease, including not just cancers but, also, viral disease -- influenza, HepC, HFVs -- as well?
If such a scenario were to pan out, we may be on the verge of closing Pandora's box -- or some of it's larger compartments.
As a lottery ticket, this one is for the biggest jackpot ever. The price for a chance at winning the grand prize...? Pocket change.
