Saturday, August 04, 2012 12:36:54 PM
you to use a very highly focused beam of high energy radiation on the tumor. This results in >90% exposure
of PS on the tumor endothelial cells which bavi can then bind to. In the grant description it talks
about patients with central lung cancer. That is patients with tumors deep within the lungs and not out
on the edges. Using too much radiation on these centrally located tumors can destroy the lung tissue.
So even using SBRT, since it will have to pass through lung tissue to irradiate the tumor, the amount of
radiation has to be limited. That is where bavi comes in. You can imagine using this combo of SBRT and bavi
on many other early-stage tumor types too. Talk about depth!
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