Avid Bioservices Inc (CDMO)

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Image from the paper.
Figure 4B, panel (ii), shows the increased localization of bavituximab in tumor vessels, indicating
that PS becomes exposed (>90%) on tumor endothelium in response to 10 Gy radiation (green).
In contrast, about 20% PS exposure and bavituximab localization was observed on the unirradiated tumor
tissue [Fig. 4C, panel (ii)]. No bavituximab localization was noted in normal rat lung exposed to 10 Gy
radiation [Fig. 4A, panel (ii)]. To confirm tumor vasculature labeling by bavituximab, vascular
endothelium was stained with a mouse anti-rat CD31 antibody [red, Fig. 4A–C, panel (i)]. Nuclei were stained
with DAPI [blue, Fig. 4A–C, panel (iii)]. Figure 4B, panel (iv), shows that the merged image of the tumor vessel is yellow.