Avid Bioservices Inc (CDMO)

[freethemice]

No. It is not clear that Bavi directly switches the neutrophils like it does with macrophages.
Thorpe specifically stated that in the case of macrophages Bavi was directly, by binding
to the macrophages, causing the switch from M2 to M1. In the paper I cited the neutrophils
do seem to be switched but it may be that the tumor microenvironment has been changed so
that neutrophils that arrive at the tumor are switched by the environment and not
directly by Bavi, but Bavi is the reason the change has occurred in the microenvironment.
In another paper, which first showed this switching from N2 to N1, the blockade of TGF-beta
was what was doing it, and Bavi by blocking PS causes a reduction in TGF-beta. I think this
was probably happening all along but nobody looked specifically at the neutrophils before.
So it is another part of Bavi's MOA.