Avid Bioservices Inc (CDMO)

[freethemice]

What is going on with bavi + docetaxel? Why is there such an increase in the MOS of the treatment arms?
This is truly a breakthrough. It was seen before in mice with breast cancer treated with bavi + docetaxel.
A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the
antitumor effect of docetaxel on human breast tumors in mice.
Huang X, Bennett M, Thorpe PE.
Cancer Res. 2005 May 15;65(10):4408-16.
FREE: http://cancerres.aacrjournals.org/content/65/10/4408.long
This image is from that paper. It shows the tumor colonies that have formed in the lungs after the breast
cancer became metastatic. Note the bar chart with the 3G4 + doc column showing that 5/10 mice had
zero tumor colonies in the lungs. This is what I think is happening to the patients in the second-line NSCLC trial.
Bavi + docetaxel has greatly reduced the metastasis in these patients and so they are not dying as quickly,
or maybe some of them are cured. Note 3G4 is the mouse version of bavituximab.
Another thing that is amazing is that the mouse models are predictive of the human results. I think this is
because bavi works with the immune system in a very basic way which is common to both mouse and human.