Buck...great find! This has to be the first reporting of bapi results in a trial and showing a benefit to patients. The Phase III's results are due in August and if significant ILNS is going to jump quickly or become a big Pharma acquisition with their patent portfolio. IMHO. Great article!
Patients Forty-six patients with mild to moderate Alzheimer disease.
Interventions Patients received either placebo (n = 19) or bapineuzumab (n = 27) in 3 or 4 ascending dose groups.
Main Outcome Measures Changes between end of study and baseline in the exploratory CSF biomarkers Aß1-42, AßX-42, AßX-40; total tau (T-tau); and phosphorylated tau (P-tau).
Results Within the bapineuzumab group, a decrease at end of study compared with baseline was found both for CSF T-tau (–72.3 pg/mL) and P-tau (–9.9 pg/mL). When comparing the treatment and placebo groups, this difference was statistically significant for P-tau (P = .03), while a similar trend for a decrease was found for T-tau (P = .09). No clear-cut differences were observed for CSF Aß.
Conclusions To our knowledge, this study is the first to show that passive Aß immunotherapy with bapineuzumab results in decreases in CSF T-tau and P-tau, which may indicate downstream effects on the degenerative process. Cerebrospinal fluid biomarkers may be useful to monitor the effects of novel disease-modifying anti-Aß drugs in clinical trials.
AI
