Avid Bioservices Inc (CDMO)

[entdoc]

sunstar, thanks. you asked about "armed missile" Bavituximab, and the potential there. I've dampened my enthusiasm lately after Thorpe was quoted as saying that unarmed Bavi- looks as good as armed, and ditto with chimeric Bavis vs. fully human Bavi. Puzzling. However, there might be an unacceptable loss of "specificity" when one of the Bavi binding sites is loaded with cytotoxic agent. You can Google "truncated tissue factor" and see the work done on tumor vessel thrombosis caused by that agent, one studied by Thorpe in the past. There are a host of "small molecule" agents being tested for anti-cancer effects. The question is whether Bavi- or anti-PS MABs are the missiles of the future that will be used to shuttle these agents to specific docking sites on tumor...or if that will even be necessary. Star-wars is here.