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Re: drbio45 post# 141226

Wednesday, 05/02/2012 10:37:10 PM

Wednesday, May 02, 2012 10:37:10 PM

Post# of 252431

the [Squalamine] eyedrop will be given twice a day.

Regardless of the route of administration and the dosing frequency, the fundamental problem with Squalamine is that it’s a relatively weak VEGF inhibitor. It was taken from nature “as is,” and was never subjected to the medicinal-chemistry optimizations that are typically done on a small-molecule drug.

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