RespireRx Pharmaceuticals Inc (RSPI)

[haysaw]

From the article I posted in #msg-74406619:

Seaside Therapeutics, Inc., of Cambridge, Massachusetts, a company Bear co-founded in 2005, has several Fragile X compounds in its clinical pipeline. One of them—a mGluR antagonist (STX107) licensed from Merck—survived Phase 1 but has languished on the backburner while the company pours resources into another compound—a GABA B receptor agonist (STX209). By ramping up inhibitory activity, this molecule achieves the same effect as mGlu5 blockers—diminished glutamate receptor signaling—but has a faster path to regulatory approval, Bear told ARF. It is the active enantiomer of a drug (racemic baclofen) already in use for cerebral palsy and gastroesophageal reflux. The company reported at meetings that the GABA B agonist improved several global measures in an open-label Phase 2 study of autistic patients (see news release). In the Fragile X Phase 2 trial, the compound showed some benefit in participants with severe social avoidance (see news release). Recruitment is underway for a Phase 3 trial of the GABA B agonist in children with Fragile X syndrome.