best narrative (fiction?)I can muster. Think Affitec. Think r94 and pgn635. Two years ago I wrote the following, and nothing has altered that truth, especially not Friday morning "news". Naked Bavi isn't going to fly (especially for andvanced cancer) if efficacy statistics must be carried to two decimal points and we argue about significance. If Bavi is going to be used its efficacy must be obvious. r94 and pgn635? Now you're talking. Someone asked, what happened to India and Russia? I posted last week that only a few people in Denmark and Russia really know what is going on with r94 and pgn635. I say that Avid and the 154 Peregrine employees are continueing to ramp up production capabilities for those two agents. Naked Bavi use is interesting, and the safety-stalking work in humans done by that mAB will smooth the way for the real beef...r94, a better Avastin, and pgn635, all-human Bavi that can safely deliver a knock out punch...time and time again because it is all-human.
Post 53989 July, 2010 Here's the deal: PPHM's monoclonal antibody Bavituximab has been used now in combination with standard chemotherapy and found to "not interfere" in any way with results of chemo/cancer treatment, but probably actually improves results. PPHMs MAB Bavituximab now has an established safety profile. That is Huge! Huge, and that safety profile is for an inferior grade MAB, one made up, in part, of mouse parts which may cause increased levels of allergic reaction. So Bavi may be safely added to standard chemotherapy. "Naked" [unarmed] Bavi was NEVER NEVER intended to be a stand-alone cancer killer. NEVER! But a lagniape that we never imagined is that BAvi is probably an immunological stimulant even when "unarmed" and used in the cancer treatment mix. And that immune boost is documented in severely immunologically crippled advanced cancer cases. But we are not, repeat NOT, in this because Bavi showed some measurable improved survival even unarmed. We, like BMY, are after the biggie: fully-armed a fully humanized MAB cancer bomb. That's the cancer killer. Not chemo. Not naked Bavi. Read my lips: it is fully armed and fully humanized Bavi. BMY has their full-humanized MAB that docks on anti-EGF. PPHM's MAB has a better, more universally applicable cancer docking site, -PS. The science is a done deal. The animal trials are finished. The theory is sound. The patents are there. The strategy is to add two known quantities together to fight cancer, fully-armed and fully human MAB Bavi. It's a no-brainer, that's where we're going. Things evolve. We're at there now. The coup de grace is to move fully armed and fully human Bavi directly into PiiB human trials. That's why we're here. That's when the PPS share kickstarts.
