![](http://investorshub.advfn.com/images/default_ih_profile2_4848.jpg?cb=0)
Sunday, March 04, 2012 2:54:30 PM
I still think it's nuts that the LIs aren't being picked up for RD. The benefit to public health that is being lost here is enormous.
http://www.empr.com/opioid-induced-respiratory-depression-central-sleep-apnea-remain-a-major-clinical-challenge/article/229464/
Opioid-Induced Respiratory Depression, Central Sleep Apnea Remain a Major Clinical Challenge
Debra Hughes
February 26, 2012
PALM SPRINGS, CA — Patients on chronic opioid treatment should be assessed for sleep-disordered breathing, as central apnea can result in a higher risk of morbidity and mortality, according to a presentation during the 2012 American Academy of Pain Medicine Annual Meeting.
In the hospital setting, incidence of opiate-induced respiratory depression is 10–15%, representing a major clinical challenge for anesthesiologists, pain medicine specialists, and intensivists. Balancing the trade-off between analgesia and sedation and respiratory depression is critically important because risk of central sleep apnea due to sleep-disordered breathing — another result of opioid usage in patients with chronic pain — can be increased with no physiological “cue,” said Lynn R. Webster, MD, Lifetree Clinical Research, Salt Lake City, UT. Case studies have found that even a single dose of an opioid can push patients into the severe category of central sleep apnea that would otherwise go undetected unless the patient was being monitored.
Risk factors for sleep apnea with chronic opioid therapy include the opioid dose, concomitant use of benzodiazepines, and age, he said, with body mass index having an inverse relationship. “Every opioid for every individual is unique; start low and titrate up,” he said.
Now that “we know where respiratory rhythm is generated,” the task remains to develop agents that can increase effectiveness of an opioid without interfering with its underlying analgesic effects, said John J. Greer, PhD, of the University of Alberta, Edmonton, Canada.
One new class of agents being explored is the ampakines, which have been shown to have respiratory stimulant effects on the brain's pre-Bötzinger complex. Specifically, an intravenous formulation of the ampakine CX717 is being developed; ideally, it could be used in conjunction with opioid drugs to reduce respiratory depression without affecting analgesia. Ampakines may also find a use in apnea of prematurity, Dr. Greer concluded.
Recent RSPI News
- Form 8-K - Current report • Edgar (US Regulatory) • 09/06/2024 12:45:11 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/02/2024 12:30:23 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/08/2024 08:01:32 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/29/2024 01:03:20 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/02/2024 01:30:27 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/22/2024 01:45:38 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 12/11/2023 01:45:18 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/17/2023 09:06:03 PM
- Form NT 10-Q - Notification of inability to timely file Form 10-Q or 10-QSB • Edgar (US Regulatory) • 11/14/2023 09:05:14 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/12/2023 01:00:21 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/02/2023 12:45:26 PM
North Bay Resources Announces Mt. Vernon Gold Mine Bulk Sample, Sierra County, California • NBRI • Sep 11, 2024 9:15 AM
One World Products Issues Shareholder Update Letter • OWPC • Sep 11, 2024 7:27 AM
Kona Gold Beverage Inc. Reports $1.225 Million in Revenue and $133,000 Net Profit for the Quarter • KGKG • Sep 10, 2024 1:30 PM
Element79 Gold Corp Announces 2024 Clover Work Plans & Nevada Portfolio Updates • ELMGF • Sep 10, 2024 11:00 AM
Nightfood Holdings Inc. Completes Major Step on Uplist Journey by Closing Strategic All-Stock Acquisition of CarryoutSupplies.com • NGTF • Sep 10, 2024 8:15 AM
Element79 Gold Corp. Announces Sale of 100% Interest in Elder Creek, North Mill Creek, and Elephant Projects to 1472886 B.C. Ltd. • ELEM • Sep 9, 2024 9:34 AM