Haysaw, The Central SA cohort was only 3 patients (out of 20), so not exactly a Phase 3. But combined with the larger Mixed SA patients, plus the data from the earlier RD study, and there is definitely POC for the upregulation of respiration.
But after Neuro explained the extreme difficulties in designing a pivotal trial for RD, it's not surprising that it's been so difficult to re-partner. SA should be easier, but the SA trial was small, and CX-1739 didn't improve Obstructive SA at all, only Mixed and Central. So.. no luck yet getting a partner.
For me, watching Cortex is just a pastime. I rarely actually owned the stock, so I haven't become as embittered as some have. I still think a bolder CEO/management could do a reverse split as part of a broad plan to recapitalize the company. But Varney seems content to just keep the salaries flowing. It's criminal that there are no funds to advance the new compounds. While everyone may hate a CEO like Bianco, he did get CTIC out of the bio morgue and back in the game. I'd rather see Cortex go out in a blaze of glory than to end with a wimper.