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Re: iwfal post# 137362

Tuesday, 02/21/2012 9:34:05 AM

Tuesday, February 21, 2012 9:34:05 AM

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i think the disappointment came because:

1. there usually is good correlation between RVR and SVR
2. 7977 surprisingly had some SVRs in naives with just ribavirin

i agree with your point that nulls, being refractory to interferon/rib, does not mean they should necessarily be refractory necessarily to DAAs any more than naives, and so point #2 above becomes more relevant to expecations since you would think the positive data in naives may have translated to nulls

(in a prior post i noted that it is reasonable to think many nulls are just resistant to inf and not ribavirin)
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