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Saturday, February 18, 2012 8:19:42 PM
2/18/2012 11:27:58 A.M. Pacific Standard Time,
Hi Madeline,
This is probably a bit premature because we need to wait to see what your blood work shows, but want you and [your oncologist]Dr. A..... to know about an anti-cancer agent in development which I have followed for several years, Bavituximab, manufactured by Peregrine Pharmaceutical. One of its clinical trials for "front-line" treatment of NSCLC has closed for patient enlistment, but there are Investigator Sponsored Trials ongoing which Dr.A.... could probably qualify to administer using Bavituximab in combination w. Pemetrexed and Carboplatin Chemotherapy. The Bavituximab (or any other experimental agent) may also be obtained for use (with other chemo- agents) under an FDA provision called "Compassionate use", a mechanism that allows patients to choose to use medications that are not fully FDA approved. There is a form to fill out on that, and if it seems appropriate, I'm sure Dr. A.... can/would help you with that too. I think the community is fortunate to have him.
All of this is an attempt to broaden your horizons to possibilities you and your doctors may not be considering...and there are others. As mentioned, though, this is one of my "pets". You can click on the web addresses below for more information. Best wishes, ....[ENTdoc]
http://www.peregrineinc.com/pipeline/bavituximab-oncology.html
http://clinicaltrials.gov/ct2/show/NCT00503347
Peregrine's Bavituximab Shows 50% Improvement in Overall Tumor ...
6 Dec 2011 ... "Across our bavituximab trials, the clinical data have been ... and best ORR was
determined at investigator sites using RECIST (Response ...
http://finance.yahoo.com/news/Peregrine-Bavituximab-Shows-iw-3497670049.html
This is a webcast from company president. Not sure you will be able to upload it:
http://www.veracast.com/bio/ceoinvestor2012/main/player.cfm?eventName=2024_peregr&appname=Microsoft Internet Explorer&os=Windows XP&wmversion=Yes - version 11.0.5721.5280&rmversion=Yes - no version info
Dear ....[ENTdoc],
I really appreciate receiving this information from you! Since we won't have the results on the Alk mutant gene test until next week, Dr. Anderson went ahead and has everything in place to start me on Chemo on Monday, Feb. 27. I went in yesterday to have a blood test, B-12 shot and talk with a nurse practitioner about Chemo. Actually, Dr. Anderson has prescribed the exact combination you have mentioned...using Bavituximab in combination with Pemetrexed and Carboplatin Chemotherapy. He also mentioned the possible use of Bavituximab as a maintenance drug after my six sessions of Chemo ends. So if the mutant gene tests negative, I'll begin Chemo on the 27th.
I'll let you know the mutant gene test results and Stanford's recommendations. I'll check out the information on the web sites you listed...thanks so much!!
Madeline
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