Biotech Values

[vinmantoo]

acgood,

Thanks for the nice history of HSP90 inhibitors and I will take a look at the companies listed. One comment about oncogenic proteins being addicted to HSP90. Mutants in oncogenic kinases don't have to rely on HSP90 for their stability, although I am sure that happens. The particular case I was speaking of was where one the level of such a mutant kinase was unaffected by HSP90 inhibition. Rather, the activity of the mutant protein was dramatically lost yet the protein remained stable. The idea was that is folded into a non-fucintonl state without full HSP90 activity.