How does this translate to Cystic fibrosis? I'm not sure what level of corrected CFTR is necessary for significant disease/symptom abatement. Not sure if it is linear, or somewhat like hemophilia in the need for less than full conversion of target genes. Also there is an issue with the larger size of the CF gene involved as opposed to the FIX gene which is about 1/3 the size, I believe. At what point is gene size a detriment to ZFN deployment and function?
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