INO up today, up volume. What's up? I posted this question in INO board, no taker;
Thank you for INO summary. Its electroporation delivery of DNA antigen is a novel idea and very interesting. But, I like to know if the company ever published a theory or fact about how the injected antigens traveled sequentially through each step in immune activating chain. Starting point is intramuscular injection enhanced by electroporation of limited area of muscle. Most of DNA injected is supposed to enter electroporated local muscle cells. This much is what I know and understand but what happens next? Is the muscle the place where antibody generated, or can the muscle cell migrate to some place to incite T-cell and antibody reaction? Or, does it excite local mechanism such as through dendric cell?
