studies state that cannabis or cannabinoids may be useful in treating alcohol abuse,amyotrophic lateral sclerosis,[collagen-induced arthritis,[ asthma,atherosclerosis,bipolar disorder,colorectal cancer, HIV-Associated Sensory Neuropathy depression,dystonia,epilepsy, digestive diseases,gliomas,hepatitis C, Huntington's disease,] leukemia, skin tumors,methicillin-resistant Staphylococcus aureus (MRSA), Parkinson's disease, pruritus, posttraumatic stress disorder (PTSD), psoriasis,[ sickle-cell disease, sleep apnea,and anorexia nervosa. Controlled research on treating Tourette syndrome with a synthetic version of tetrahydrocannabinol, (brand name Marinol) (the main psychoactive chemical found in cannabis), showed the patients taking Marinol had a beneficial response without serious adverse effects; other studies have shown that cannabis "has no effects on tics and increases the individuals inner tension". Case reports found that marijuana helped reduce tics, but validation of these results requires longer, controlled studies on larger samples.