In vivo Raman spectroscopy of the skin: advances and issues for clinical implementation
Paper 8207A-29
Time: 12:15 PM - 12:35 PM
Author(s): Isaac J. Pence, Elizabeth Vargis, Quyen Nguyen, Chetan Patil, Vanderbilt Univ. (United States); Darrel Ellis, Vanderbilt Univ. Medical Ctr. (United States); Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)
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Clinical diagnosis of skin lesions is often difficult because of the subjective nature of visual inspection and the potential for sampling error in biopsy. We are investigating Raman spectroscopy for non-invasive classification of skin lesions; however, high levels of physiological and anatomical variability in benign skin can complicate optical diagnosis. Understanding of skin variability both between patients and within a single patient may lead to improved diagnostic outcomes. Here, we present a Raman spectroscopy study of in vitro and in vivo measurements addressing practical and experimental issues associated with clinical implementation of Raman spectroscopy for real-time detection of cutaneous malignancies.
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