Avid Bioservices Inc (CDMO)

[entdoc]

geo: post73469:careful who you get into bed with: new years thoughts of Bavi+ Ribavirin trials:
-Ribavirin MOA (mechanism of action) is to reduce intracellular
synthesis and storage of guanine, a nucleotide “building
block” necessary for DNA and RNA synthesis.
-Ribavirin thus inhibits viral replication and body immune cell replication?
-Ribavirin interferes with reproduction of rapidly proliferating
cells. Also, cells with a high rate of protein turnover.
-Therefore ribavirin side effects include nausea and immunosuppression.
- Ribavirin alone (monotherapy) has little effect on HCV {hepatitis C virus}RNA levels, and is associated with a decline in serum ALT, suggesting that ribavirin may not be acting as an
antiviral agent, but rather as a modulator of immune
system function.
-Ribavirin monotherapy for HCV is ineffective, and the drug is only approved for use in combination with interferon.
http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Inf%20and%20Rib_08.pdf
The implications of this are mind-boggling.

you asked, "Isn't it also known that Bavi will work best if paired with another agent that increases the PS on bad cells (chemo, irradiation, etc)?