Avid Bioservices Inc (CDMO)

[entdoc]

puzzlinger&puzzlinger:
-Someplace along the way to market double-armed MAB missile Bavituximab, capable of carrying a cancercidal payload directly to tumor vasculature, is found to be mildly stimulating to the immune system when used unarmed, or "naked", against cancers and viruses.
-Bavi is then paired with Ribavirin to treat HCV, and Ribavirin is a drug which, if used alone, has little if any effect on HCV {hepatitis C virus}RNA levels; is associated with a decline in serum ALT; is probably an immunomodulator; might even be immunosuppressive; and can only be used for HCV paired with interferon.
some possible conclusions while trying to connect the dots...
anyone?
trial design?
FDA barriers to new drug entry?
who on earth paid for this trial?
benefits of pairing Bavi with immunosupprssant chemo agents?
maybe interferon + Bavi makes more sense.
using Bavi in end-stage disease when the immune system is spent rather than in early disease?