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DewDiligence

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Re: pcrutch post# 132110

Wednesday, 11/30/2011 3:50:40 PM

Wednesday, November 30, 2011 3:50:40 PM

Post# of 252614
As compared to the first-generation HCV PI’s, TMC435 is more specific to the HCV protease and hence is less apt to cause the kind of off-target effect on a host protease that jellybean is talking about. Still, I don’t think we can entirely rule out the possibility that some nuke+PI combinations could fail due to the PI interfering with the metabolism of the nuke’s prodrug.

“The efficient-market hypothesis may be
the foremost piece of B.S. ever promulgated
in any area of human knowledge!”

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