Avid Bioservices Inc (CDMO)

[RRdog]

This award to Siro (the Indian Clinical Co.) and the mutual admiration with PPHM has a "connect the dots" feel to it. IMO only---Gupta ran the trials for this company and PPHM and ran them meticulously well. Something about the way he placed the catheters or some other technical factor gave Gupta outstanding results.

Gupta speaks in the US at Neurosurgical Conference which has reason to want to hear his remarks.

Neurosurgeons desirous of a new surgical technique to treat GBM and do more business.

PPHM in a very "PC" position at the FDA with both the NIH (developer of the catheter/convection technique) and the Assoc of Neurosurgeons behind this approach at the FDA.

FDA desirous of a new method to treat this most deadly of disease for humanitarian reasons.

FDA is " highly probable" IMO to grant PPHM a reasonable PHase III pathway that would be acceptable to prospective partners.

FDA IMO now better than 50/50 to grant SPA.

IMO,believe CP comments on this board about the FDA receiving all data first, then submitting questions to PPHM before scheduling meeting essentially correct. This is the most efficient way to proceed.

Looking forward to further developments in this particular area.

Best Regards,
RRdog