Proteonomix Inc. (PROT)

[Sheeple O Plenty]

Part 2: Extracted from the White Paper "Secreted Matrix™ and Matrix NC-138™" by Michael Cohen

Function:
Proteins are important signal transducing molecules in cells. In fact, diseases such as diabetes and certain forms of cancer, among other pathologies, are thought to arise due to derangement of protein signaling.

Types of protein signaling:
Protein can refer to two distinct families of proteins. Heterotrimeric proteins sometimes referred to as the large proteins that are activated by specific proteincoupled receptors. There are also small proteins (20-25kDa).

Heterotrimeric proteins:
Heterotrimeric proteins share a common mode of action, i.e., activation in response to a conformation change in the protein-coupled receptor and dissociation in order to activate further proteins in the signal transduction pathway. However, the specific mechanism differs between different types of proteins.

Activation:
When a ligand activates the protein-coupled receptor, it induces a conformation change in the receptor (a change in shape) that allows the receptor to function. In the traditional view of heterotrimeric protein activation, it can then activate different signaling cascades (or second messenger pathways) and effector proteins.

Termination:
The activated protein receptor will eventually hydrolyze and disassociate from the heterotrimeric activating protein.

Matrix NC-138™:
Bioactive proteins have been defined as specific protein that have a positive impact on body functions or conditions and may ultimately influence health. The activity of these biofunctional proteins contained in the isolated Secreted Matrix™ is based on their inherent amino acid composition and sequence. The length of active proteins may vary from two to more than 100 amino acids and are known to have multifunctional properties. Matrix NC-138™ is a further isolation of Secreted Matrix™ for the specific bioactive proteins whose action on skin is to enhance activities through stimulation of collagen production, glandular production or reduction of wrinkles. This is the efficacy of the Proteoderm Matrix NC-138™ product as demonstrated in vitro and in vivo at University Laboratory studies. Our University Laboratory in vivo studies demonstrated high level of efficacy of Matrix NC-138™.These laboratory studies correlate with our on going large scale clinical trials.