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Post# of 252545
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Alias Born 07/03/2007

Re: p3analyze post# 123205

Monday, 07/11/2011 9:59:53 PM

Monday, July 11, 2011 9:59:53 PM

Post# of 252545
Note ONTY/Merck would not be the only one jumping on the Mucin bandwagon, there is also Transgene/Novartis.

Back when I was following ONTY more closely I looked at Transgene's TG4010 muc1 vaccine as a comparator. It's different from Stimuvax in that it's a littler longer than a 5 repeat sequence of the core muc1 peptide in a poxvirus delivery vehicle. Redplate posted once that it was to get around the basic muc1 patents that ONTY licensed. Transgene ran a ph II combo trial in stage III/IV NSCLC with similar OS result in terms of ITT missed, but a sub-group was found that was lo and behold stat sig. I haven't followed it since but Transgene was looking to move to ph III.

p.s. good to see you P3!

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