The important part of Tdox is NOT the heat - heat only activates it - breaking down the "soccer balls" and allowing the doxorubicin to escape.
Also, RFA itself is a great intervention. But keep in mind what Tdox does - it bathes the areas, where ablation doesn't "quite" reach the effective temperature, with the chemo agent and kills off those tumor cells that aren't done in by the heat. There's also some evidence that the dox then kills off the micromets that would later cause metasteses elsewhere in the body. This new tech won't have that benefit.
This may interfere with RFA, but not with Tdox.
Regards,
Trond
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