I assume the hypothesis was based on the observation that C-terminal peptide segments within Abeta(1-40) and Abeta(1-42) have distinct structures, but I think a stronger reason for targeting N-terminus of the Abeta protein was because epitope mapping of sera antibodies isolated from AD patients immunized with the late AN-1792, revealed that the anti Abeta antibodies generated by the vaccine, primarily recognized the N-terminal residues of the peptide.
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