Well, that's a typical MD for you. What is the BS about "We never realized that the brain was so important, ..."??? People have been looking into that for decades, and it would do this Dr. Bhoyrul some good if he followed the literature both in animals and humans.
As for ghrelin antagonists, they usually target the GHS-R1A receptors, which are also growth hormone receptors (GH). You would want to be very careful with manipulation of this system. I know of one test with ghrelin antagonist in type 2 diabetic patients, that evaluates its effect on glucose homeostasis, but not anything with obesity.
