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Re: BTH post# 121181

Tuesday, 06/07/2011 2:00:28 PM

Tuesday, June 07, 2011 2:00:28 PM

Post# of 252455

So are you saying that even though Ariad's 113 could be more potent against ALK, the cancer develops resistance through other pathways that '113 doesn't inhibit?

That’s exactly my point. A second-line ALK inhibitor may not get the job done if a patient’s resistance to Crizotinib comes from activation of other oncogenes, which is likely to be the case in many instances.

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