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Monday, June 06, 2011 8:34:19 PM
Diwan has been working on this for twenty years.
That's why I think it can be done in less than 2 years. OK, not entirely and not really the reason.
25 years ago, Diwan worked on a process for moving molecular structures through a liquid medium. 20 years ago he co-developed self-assembling water soluble nano-structures. The only thing any of the developers knew was that the implications and applications might be limitless. Diwan took his idea for the next 10 or so years to work on the central structure to develop a method of adding layers to make the structure useful. Nothing useful about a "soap bubble" that self-ssembles to exactly 20 nm, it's really cool, but not yet useful.
He discovered a way to add a second layer with properties that allowed certain types of molecules to a attach to the surface. Because the nanomicelles were hollow, he also found a way to place compatible chemicals into the cenert, which would allow the particle to become a carrier of those chemicals. Somewhere along the line, he (I need to correct here to say that Diwan includes his team, Onton and later Tatake) got the idea to apply the nanomicelle technology to carrying drugs and the attaching properties of the outer layer to apply ligands and target cells. The idea was to carry drugs to target cells to increase the efficacy. Whence, arose the name Therapeutic Carrier, TheraCour.
It wasn't until about 2003 or 2004 that he began playing with the idea of targeting viruses, mainly to deliver a more effective dose of some HIV antiviral. In early 2005, he with Kard did a proof of concept model at the labs in Beth Isreal Deaconess Hospital, and the team, only looking for evidence of targeting ability found that the ligand charged nanomicelle itself destroyed the test virus, the CMV that appears in the micrographics images in the iBOX for this thread. It was only then that Nanoviricides were born.
So, although Diwan has been playing with Self-assembling nano particles for a couple of decades, nanoviricides are something less than 7 years old. And this progression is what makes me think that the INDA will be ready soon.
Influenza transmission and replication simply explained:
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