i botched the reply. all i wanted to bring across is that the SOC - standard of care for specific type of cancers is pretty much a known result - easily quantifiable based on the last 1-20 yrs research which has not changed much.
example - pancreatic cancer patient - on standard soc lives 6 months
trying a new agent - oncolytic virus yields 24 months in combo with SOC.
what is the value of subjecting those patients to another round of SOC when you know the outcome - 6 months
hence my reservation about randomized trials. There is a place early in the drug life perhaps ...but not everytime you test a new drug...
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