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Re: ariadndndough post# 7781

Saturday, 05/07/2011 2:08:58 PM

Saturday, May 07, 2011 2:08:58 PM

Post# of 80490

[ALK] is a space (like CML) where preclinical results are highly predictive of clinical results....


This is an interesting statement/contention -- with ALK so new a target, why are we confident?

Everything else I think makes sense, but the idea that there is a whole class of compounds whose path through the clinic is well predicted by in vitro or mouse models seems, well, rather optimistic.

I would be very interested to know more about why we think this.

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