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DonShimoda

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DonShimoda

Re: rkrw post# 7704

Thursday, 05/05/2011 2:09:21 PM

Thursday, May 05, 2011 2:09:21 PM

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Mutations only arise *after* treatment. Same as with BCR ABL drugs.


This is far less definitive than your statement implies.

"Evidence has emerged suggesting that cells bearing the T315I mutation may be present *early* in the disease and undergo expansion following elimination of their drug-sensitive counterparts."

See "Targeting the Resistance in CML" http://www.hematology.org/Publications/Hematologist/2010/4827.aspx
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